Ham, Young
Associate Professor - Organic Chemistry
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Last Updated: 11/27/15 -





yham@uvu.edu; (801) 863-8638


Department of Chemistry, Utah Valley University

800 W. University Pkwy. Orem, UT 84058



Employment and Professional Experience

2015 –                       Associate professor, Utah Valley University, Orem, UT

2014 –                       Consultant, Turner Innovations, Orem, UT (Polymer Chemistry)

2012 – 2015            Assistant professor, Utah Valley University, Orem, UT

2006 – 2012            Assistant professor, Brigham Young University, Provo, UT

2004 – 2006            Senior Research Scientist, Molecular Therapeutics, Inc. Ann Arbor, MI (Polymer Chemistry)                 



2002 – 2004            Post-doctoral Associate, The Scripps Research Institute, La Jolla, CA                                                                Adviser: Professor Dale L. Boger


1997 – 2002            Ph.D. Organic Chemistry, Purdue University, West Lafayette, IN

Adviser: Professor Jean Chmielewski

Dissertation title: “Development of the HIV-1 Protease Dimerization Inhibitors Using Focused Library Approaches”


1994 – 1996            M.Sc. Organic Chemistry, Hanyang University, Seoul, Korea

Adviser: Professor Soon Yung Hong

Thesis title: “Synthesis of the Novel 1b-methyl carbapenem Antibiotics and Their Antibacterial Activities”


1988 – 1992            B.Sc. Chemistry.  Hanyang University, Seoul, Korea


Research Experience

Organic Chemistry

2014 – present        - Design and synthesis of anti-inflammatory compounds targeting STAT3 and NF-kB  


2006 – 20012         - Design and synthesis of RNA binding small molecules based on 2-

                                      deoxystreptamine as antibiotics

- Design and synthesis of riboswitch aptamer binding molecules.

2002 – 2004            - Solution-phase synthesis of DNA binding/alkylating agents based on

Distamycin A and Duocarmycins

- Development of a selection assay for DNA alkylating agents of Duocarmycin analogs

1997 – 2002            - Design and preparation of a library of HIV-1 protease dimerization inhibitors based  

                                      on crosslinked interfacial peptides of the protease          

- Development of the HIV-1 protease inhibitors for covalent reversible inhibition

- Design and synthesis of b-sheet and helix-turn-helix peptides for self-replication

1994 – 1996            - Synthesis of novel 1b-methyl carbapenem antibiotic derivatives


Polymer Chemistry

2014 – present        - Development, characterization, and analysis of heavy metal containing acrylics as   

                             transparent radiation shielding through radical polymerization

2004 – 2006            - Development of biodegradable polymer nanoparticles for drug delivery using 

   radical polymerization, encapsulation of small molecule drugs and imaging contrast  

   agents, and functionalization on the surface of the nanoparticles for targeted



Teaching Experience

Aug. 2012 –            Assistant professor, Utah Valley University, Orem, UT

Organic Chemistry I (CHEM 2310)

Organic Chemistry II (CHEM 2320)

Organic Chemistry Laboratory II (CHEM 2325)


2006 – 2012            Assistant professor, Brigham Young University, Provo, UT

-               Undergraduate courses:

Introduction to Organic Chemistry (CHEM 152)

Organic Chemistry I (CHEM 351)

Organic Chemistry II (CHEM 352)

-               Developed a new course: Special Topic Graduate course:

Bioorganic Chemistry (CHEM 695R)


1997 – 2000            Department of Chemistry, Purdue University

      Head TA for organic chemistry lecture for chemistry majors (2 semesters)

      Teaching assistant for organic chemistry laboratories (4 semesters)


Scholarly Publications        

  1. Oh, S.B.; Hwang, C.J.; Song, S.Y.; Jung, Y.Y.; Yun, H.M.; Sok. C.H.; Yi, J.M.; Park, D.H.; Ham, Y.W.; Han, S.B.; Hwang, B.Y.; Hong, J.T. Anticancer effect of Tectochrysin in NSCLC cells through overexpression of death receptor and inactivation of STAT3. Cancer. Lett. 2014, in press.


  1. Kim, J.A.; Yun, H.M.; Jin, P.; Lee, H.P.; Han, J.Y.; Venkatareddy, U.; Moon, D.C.; Han, S.B.; Oh, K.W.; Ham, Y.W.; Jung, H.S.; Song, H.S.; Hong, J.T. Inhibitory Effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatoy reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells.  Nephropharmacology. 2014, 79, 476-487.


  1. Ban, J.O.; Kim, D.H.; Lee, H.P.; Hang, C.J.; Shim, J.H.; Kim, D.J.; Kim, T.M.; Jeong, H.S.; Nah, S.S.; Chen, H.; Dong, Z.; Ham, Y.W.; Kim, Y.; Han, S.B.; Hong, J.T. Anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal are mediated by inhibition of the STAT3 pathway. Br. J. Pharmacol. 2014, 171(11), 2900-2912.


  1. Song, S.Y.; Jung, Y.Y.; Hwang, C.J.; Lee, H.P.; Sok, C.H.; Kim, J.H.; Lee, S.M.; Seo, H.O.; Hyun, B. K.; Choi, D.Y.; Ham, Y.W.; Hong, H.T. Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-kB activation in cultured astrocytes and microglial cells. J. Neuroinflammation 2014, 11(1), 118.  


  1. Ban, J.O.; Jung, Y.S.; Kim, D.H.; Park, K.R.; Yun, H.M.; Lee, N.J.; Lee, H.P.; Shim, J.H. Jeong, H.S. Lee, Y.H.; Ham, Y.W.; Han, S.B.; Hong, J.T. (E)-2,4-Bis(p-hydroxyphenyl)-2-butenal inhibits tumor growth via suppression of NF-kB and induction of death receptor 6. Apoptosis. 2014, 19, 165-178.


  1. Lee, N.J.; Oh, J.H.; Ban, J.O.; Shim, J.H.; Lee, H.P.; Jung, J.K.; Ahn, B.W.; Yoon, D.Y.; Han, S.B.; Ham, Y.W.; Hong, J.T. 4-O-Methylhonokiol, a PPARg agonist, inhibits prostate tumor growth: p21-mediated suppression of NF-kB activity. Br. J. Pharmacol. 2013, 168(5), 1133-1145.


  1. Venkatareddy, U.; Ham, Y.W.; Fosso, M. Y.; Chan, K. Y.; Rai, R.; Zhang, J.; Lie, J.; Chang, C.T. Investigation of antibacterial mode of action for traditional and amphiphilic aminoglycosides. Bioorg. Med. Chem. Lett. 2013, 23(6), 1671-1675.


  1. Lee, U.S.; Ban, J.O.; Yeon, E.T.; Lee, H. P.; Venkatareddy, U.; Ham, Y.W.; Hong, J.T. Growth Inhibitory Effect of (E)-2,4-bis(p-hydroxylphenyl)-2-butenal diacetate through induction of apoptotic cell death by increasing DR3 Expression in Human Lung Cancer Cells. Biomol. Ther. 2012, 20(6), 538-543.


  1. Ham, Y.W.; Humphreys, D. J.; Choi, S.; Dayton, D. L. Rational Design of SAM Analogues Targetting SAM-II Riboswitch Aptamer.  Bioorg. Med. Chem. Lett. 2011, 21(17), 5071-5074.


  1. Venkatareddy U.; Chittapragada, M.; Marble, J. B.; Dayton, D. L.; Ham, Y.W. Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond. Bioorg. Med. Chem. Lett. 2011, 21(16), 4713-4715.


  1. Roberts, S. R.; Chittapragada, M; Pendem, K.; Leavitt, B. J.; Mahler, J. W.; Ham, Y.W. Synthesis of 2,4,5-triaminocyclohexanecarboxylic acid as a novel 2-deoxystreptamine mimic. Tetrahedron Lett. 2010, 51, 1779-81.


  1. Chittapragada, M.; Roberts, S.; Ham, Y. W. Shultz, M. D.; Ham, Y.W. Aminoglycosides: Molecular Insights on the Recognition of RNA and Aminoglycoside Mimics. Perspect. Med. Chem. 2009, 3, 21-37.


  1. Ham, Y.W.; Boger, D. L.  A Powerful Selection Assay for Mixture Libraries of DNA Alkylating Agents.  J. Am. Chem. Soc. 2004, 126(30), 9194-9195.


  1. Shultz, M. D.; Ham, Y.W.; Lee, S.G.; Davis, D.A.; Brown, C; Chmielewski, J. Small-Molecule Inhibitors of Wild-Type and Mutant HIV Protease: A Focused Library Approach. J. Am. Chem. Soc. 2004, 126(32), 9886-9887.


  1. Ham, Y.W.; Tse, W.; Boger, D. L.  High Resolution Assessment of Protein DNA Binding Affinity and Selectivity Utilizing a Fluorescent Intercalator Displacement (FID) Assay.  Bioorg. Med. Chem. Lett. 2003, 13(21), 3805-3807.


  1. Issac, R.; Ham, Y.W.; Chmielewski, J.  The design of self-replicating helical peptides.  Curr. Opin. Struct. Biol. 2001, 11(4), 458-463.


  1. Shultz, M. D.; Bowman, M. J.; Ham, Y.W.; Zhao, X.; Tora, G.; Chmielewski, J. Small-molecule inhibitors of HIV-1 protease dimerization derived from cross-linked interfacial peptides.  Angew. Chem. Int. Ed. 2000, 39(15), 2710-2713.


  1. Nam, K. H.; Oh, C. H.; Ham, Y.W.; Lee, K.S.; Cho, J. H.  Synthesis and antibacterial activities of new 1b-methyl carbapenem having a 1,3-diazabicyclo[3.3.0]octan-2,4dione moiety.  Archiv der Pharmazie. 1997, 330(8) 268-270.  


  1. Oh, C. H.; Ham, Y.W.; Hong, S.-Y.; Cho, J. H.  Synthesis and antibacterial activities of new 1b-methyl carbapenem having a thiazolo[3,2-a]benzimidazole moiety.  Archiv der Pharmazie. 1995, 328(3) 289-291.   




                                    Reddy, G. R., Erathodiyil, N.; Ham, Y.-W.  Biodegradable polymer nanoparticles for therapeutic and diagnostic agents. PCT Int. Appl. (2006), 86 pp.



Funding for Scholarly Works

  • UVU School of Science SAC Grants: Y2012-13 ($5,000), Y2013-14 ($4,500)
  • UVU GEL Grants: Y2012-13, Y2013-14 in collaboration with Profs. Daren Heaton, Merrill Halling, & Craig Thulin
  • BYU MEG Grants: Y2009-10 ($20,000)


Scholarly Presentations (Posters and Seminars)

June 2014                ACS NORM, Missoula, MO. Poster Presentation “Synthesis of (E)-4,4'-(prop-1-ene-1,3-diyl) diphenol analogues as Inhibitors of NF-kB pathway”

Feb. 2014                 UCUR, BYU, Provo, UT. Poster Presentation “Design and Synthesis of (E)-2,4-Bis(p-hydroxyphenyl)-2-butenal analogues as IKKb Inhibitors”

June 2012                ACS NORM, Boise, ID. Poster Presentation “Dimeric 2-Dexoy streptamine mimic with Amide and Urea Connectivity” 

June 2008                ACS NWRM, Park City, UT. Poster Presentation “Rational design of aminoglycosides peptidomimetics”


June 2012                School of Pharmacy, Chungbuk National University, South Korea

Nov. 2011                Northern Arizona University, Flagstaff, AZ

Oct. 2011                 UNLV, Las Vegas, NV

Nov. 2010                Utah State University, Logan, UT

Oct. 2010                 Idaho State University, Pocatello, ID


Research Collaborators

  • Prof. Jin Tae Hong, School of Pharmacy, Chungbuk National University, South Korea
  • Prof. Tom Chang, Department of Chemistry, Utah State University, Logan, UT
  • Profs. Daren Heaton, Merrill Halling and Craig Thulin, Department of Chemistry, UVU 



Professional Level Services                 

2008 – 2014            Served as a manuscript reviewer for peer-reviewed journals

  • Biomacromolecules
  • ChemBioChem
  • Tetrahendon
  • Tetrahedron Lett.
  • Bioorg. Med. Chem. Lett. 

2009 – 2012            Alternate Councilor, Central Utah Region of the American Chemical Society

2008                          Co-chair/co-organizer of Bioorganic Chemistry Symposium with Prof. Heidi Vollmer-Snarr, Rocky Mountain Regional ACS meeting at Park City, UT


Department/College/University Level Services

2014-15  UVU Organic chemistry faculty hiring committee chair

2013                          UVU Chemistry Department Seminar “Food Browning Reactions and Cancer”

2012                          UVU Chemistry Department Seminar “Fight Against HIV: HIV-1 Protease Dimerization Inhibitors”

2012 – present        Hiring Committee, Department of Chemistry, UVU

2006 – 2012            Graduate Recruiting Committee, Department of Chemistry, BYU

2006 – 2012            Internal Grant Review Committee (ORCA/MEG Review), College of Physical and Mathematical Sciences, BYU

2008-09  Referee at College Spring Research Conference, BYU



Voluntary/Community Services

Sep. 2013                 Workshop presentation at 8th Annual Empowering Your Tomorrow (EYT) boy’s Conference, UVU

2012, 2013              Presentation at National (and UVU) Chemistry Week Science Demo for Community at UVU

Apr. 2013                 Science Demo Presentation with Prof. Daren Heaton for UCAS students at Science & Health Open House, UVU

2012-2014               Participation in “Pie Your Professor” for Chemistry Club Fund raising, UVU



1997 – present        American Chemical Society, Organic Chemistry Division