Tauzin, Sebastien
Title:
Assistant Professor - Biotechnology
Office:
SB 242y
Phone:
801-863-5675
Mail Code:
840
S Tauzin - CV
Last Updated: 10/24/18 -

 

EDUCATION

Institution and Location

Degree

Year(s)

Field of Study

University of Geneva, Switzerland and Bordeaux 1, France

Ph.D.

2003-2008

Cell Biology and Pathophysiology

University of Bordeaux 1, France

Master

2000-2003

Pathophysiology

University of Bordeaux 1, France

BS

1996-2000

Cell Biology and Physiology

 

TEACHING PHILOSOPHY

I have three goals as a teacher of undergraduate and graduate students. First, I try to help them succeed at the college level in a general sense – do they know how to take notes, study from their notes, prepare for a lab session, take responsibility for their own learning, work as part of a team? Secondly, I hope to convey the importance of scientific understanding as part of citizenship, and the acquisition and sharing of knowledge as a form of social responsibility. Finally, I hope to inspire and prepare at least some of them to thrive in a scientific career, whether that means working as technicians in industry, as policymakers, as researchers in academia, or whatever they become – do they understand basic principles of science? Can they interpret and represent data and communicate science well to scientists and non-scientists? Are they ethical in the way they conduct and report on their work?

To achieve these goals, I’m using active learning pedagogies to foster student’s success. My lectures are interactive and complemented with in-class POGIL and Case Study activities. In my research lab, I aim to promote an environment that guide students toward a path where they can take ownership of their work.

 

CLASSES TAUGHT

BIOL 1010-Introductory Biology

BTEC 2020-Protein Purification and Analysis

BIOL 3400-Cell Biology

BIOL/CHEM 3600-Biochemistry

BIOL 489R-Student Research

BTEC 490R-Cell Signaling and Cancer

BIOL 494R-Student Seminar

 

RESEARCH INTEREST

With my research students, we are excited about learning and investigating how cell migration affects normal and pathological conditions in the human body. We are particularly interested in deciphering the molecular mechanisms of the resolution of inflammation. This is an important topic because un-proper resolution of inflammation or unresolved inflammation is involved in the onset or aggravation of the two major diseases in developed country: Cardiovascular diseases and Cancer.

The inflammatory response in organs usually ensures host protection from pathogens and tissue repair after injuries. Sometimes, however, inflammation can induce an intense accumulation of neutrophils in the injured tissue that may result in severe local damage and loss of function. Neutrophils are essential cells to combat pathogens, but their build-up can aggravate tissue and organ inflammation. This inappropriate neutrophil accumulation was hypothesized to be the result of deficient neutrophil resolution from damaged tissue. This phenomenon is called unresolved inflammation. Unresolved inflammation has recently emerged as a strong candidate to explain the occurrence of many inflammatory-related pathologies.

During my postdoc at the University of Wisconsin-Madison, I uncovered a new mechanism involved in neutrophil migration that contributes to the resolution of neutrophil inflammation. I showed for the first time that macrophages contribute to the resolution of inflammation by inducing neutrophil reverse migration.

At UVU, we want now to complement this striking observation by the depiction of the molecular mechanism causing the reverse migration of neutrophils. Using genetic approach in zebrafish and in vitro cell migration assays, we aim to identify the molecular details required for the proper resolution of inflammation via macrophages.

 

PUBLICATIONS

1. Powel D.*, Tauzin S.*, Hind LE., Deng Q. and Huttenlocher A., Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Reports. 2017 May 23;19(8): 1572-1585.

2. Dieterich P., Lindemann O., Leif Moskopp M., Tauzin S., Huttenlocher A., Klages R., Chechkine A. and Schwabb A., Asymmetric anomalous diffusion in neutrophil chemotaxis. In preparation for PNAS.

3. Monet M., Poët M., Tauzin S., Fouqué A., Cophignon A., Lagadic-Gossmann D., Vacher P., Legembre P., Counillon L., The cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motility. Scientific Reports. 2016 Jun 15;6:28008.

4. Tauzin S., Starnes TW., Lam PY. and Huttenlocher A., Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. Journal of Cell Biology. 2014 Dec 8;207(5):589-98. Highlighted in Journal of Cell Biology, and at least a dozens of scientific websites.

5. Edmond V., Dufour F., Poiroux G., Shoji K., Malleter M., Fouqué A., Tauzin S., Rimokh R., Sergent O., Penna A., Dupuy A., Levade T., Theret N., Micheau O., Ségui B., Legembre P., Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility. Oncogene. 2015 Feb 19;34(8):996-1005

6. Shelef MA., Tauzin S., Huttenlocher A., Neutrophil migration: moving from zebreafish models to human autoimmunity. Immunological Reviews. 2013 Nov;256(1):269-81.

7. Malleter M.*, Tauzin S.*, Bessede A., Castellano R., Goubard A., Godey F., Levêque J., Jézéquel P., Campion L., Campone M., Ducret T., MacGrogan G., Debure L., Collette Y., Vacher P., Legembre P., CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer. Cancer Research. 2013 Nov 15;73(22):6711-21.

8. Penna A., Khadra N., Tauzin S., Vacher P., Legembre P., The CD95 signaling pathway; To not die and fly. Communicative and Integrative Biology. 2012 Mar 1;5(2):190-2.

9. Tauzin S., Debure L., Moreau J.F., Legembre P., CD95-mediated cell signaling in cancer: mutations and post-translational modulations. Cellular and Molecular Life Science. 2012 Apr;69(8):1261-77.

10. Tauzin S.*, Chaigne-Delalande B.*, Sophie Daburon S., Ducret T., Counillon L., Contin-Bordes C., Blanco P., Moreau J.F., Vacher P. and Legembre P, The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway. PLoS Biology. 2011 Jun;9(6):e1001090. Epub 2011 Jun 21.

11. Pizon M., Rampanarivo H., Tauzin S., Chaigne-Delalande B., Daburon S., Castroviejo M., Moreau P., Moreau J.F. and Legembre P., Actin-independent exclusion of CD95 by PI3K/AKT signaling: implications for apoptosis. European Journal of Immunology. 2011 Aug;41(8):2368-78.

12. Rubbia-Brandt L., Tauzin S., Brezault C., Dousset B., Majno P., Mentha G., and Terris B., Gene expression profiling provides insights into pathways of Oxaliplatin related Sinusoidal Obstruction Syndrome in humans. Molecular Cancer Therapeutics. 2011 Apr;10(4):687-96.

13. Tauzin S.*, Ding H.*, Burdevet D., Borisch B. and Hoessli D. C., Membrane-associated signaling in human B-lymphoma lines. Experimental Cell Research. 2011 Jan 15;317(2):151-62.

14. Olleros M.L., Vesin D., Fotio A.L., Santiago-Raber M.L., Tauzin S., Szymkowski D.E. and Garcia I., Soluble TNF, but not membrane TNF, is critical in LPS-induced hepatitis. Journal of Hepatology. 2010 Dec;53(6):1059-68.

15. Fotio A.L., Olleros M.L., Vesin D., Tauzin S., Bisig R., Dimo T., Nguelefack T.B., Dongo E., Kamtchouing P., and Garcia I., In vitro inhibition of lipopolysaccharide and mycobacterium bovis bacillus Calmette Guérin-induced inflammatory cytokines and in vivo protection from Dgalactosamine/ LPS -mediated liver injury by the medicinal plant Sclerocarya birrea. International Journal of Immunopathology and Pharmacology. 2010 Jan-Mar;23(1):61-72.

16. Yerli S., Ding H., Tauzin S., van Echten-Deckert G., Borisch B. and Hoessli D. C., The sphingolipid-rich rafts of ALK+ lymphomas downregulate the Lyn-Cbp/PAG signalosome. European Journal of Haematology. 2010 Aug;85(2):93-8

17. Ding H., Tauzin S. and Hoessli D. C., Phytochemicals as modulators of neoplastic phenotypes. Pathobiology. 2009. 76: 55-63.

19. Tauzin S., Ding H., Borisch B. and Hoessli D. C., Signaling in Human B-Lymphoma Rafts. Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Immunology‚ Endocrine and Metabolic Agents). 2008. 8: 366-374 (369).

20. Tauzin S., Ding H., Khatib K., Ahmad I., Burdevet D., van Echten-Deckert G., Lindquist J. A., Schraven B., Din N. U., Borisch B. and Hoessli D. C., Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. Blood. 2008. 111: 2310-2320.

21. Hoessli D. C., Tauzin S., Khatib K., Ding H. and Borisch B., Interference of Rituximab with plasma membrane domain organisation and transmembrane signaling in lymphoma cells. In Signpost, B. B. R. (Ed.). 2007.

22. Hoessli D. C., Tauzin S., Nasir-ud-Din and Borisch B., Functional and Structural Roles of GPI Moieties in Mammalian Plasma Membranes. Current Organic Chemistry. 2007. 11: 619-626 (618).

* Equal contribution